Synthesis of imidazol-1-yl-acetic acid hydrochloride: A key intermediate for zoledronic acid
نویسندگان
چکیده
A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.
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ورودعنوان ژورنال:
- Beilstein Journal of Organic Chemistry
دوره 4 شماره
صفحات -
تاریخ انتشار 2008